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Maternal serum C - reactive protein and fibrinogen concentration in women with pre-eclampsia
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Mohammad Abedi Samakoosh   , Shahla Yazdani * , Zinatosadat Bouzari , Masoumeh Golsorkhtabaramiri |
| Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran |
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Abstract: (11302 Views) |
Background: Despite many studies published in recent years concerning pathogenic mechanisms of pre-eclampsia, but this issue remains controversial. The aim of the present study was to compare C-reactive protein (CRP) level and fibrinogen concentration obtained from pregnant women with pre-eclampsia with those obtained from women with normal pregnancies.
Methods: In a case-control study, 40 pregnant women with mild pre-eclampsia were studied. The maternal serum CRP and fibrinogen concentration of the 40 patients were compared with 55 pregnant women with non-preeclampsia as a control group. CRP was examined using quantitive nephlometry and fibrinogen concentration was measured by clotting system. An independent sample t-test was used for analysis.
Results: Maternal serum CRP was higher in women pregnant with pre-eclampsia compared with those from pregnant women normal pregnancies (p= 0.01). The independent t-test did not reveal any statistically significant differences in the fibrinogen concentration between these pregnant women, either with or without pre-eclampsia.
Conclusion: The findings of this study indicated that a novel increased CRP was identified among pregnant women with pre-eclampsia, making inflammatory marker as a promising new approach for the detection of pre-eclampsia. |
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| Keywords: CRP analysis, Female, Fibrinogen, Inflammatory marker, Pregnancy Complications |
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Full-Text [PDF 176 kb]
(3765 Downloads)
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Type of Study: Original Research |
Subject:
Obstetrics and Gynecology
Received: 2015/04/6 | Accepted: 2015/06/24 | Published: 2015/06/29
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