Volume 10, Issue 2 (12-2024)
Caspian J Reprod Med 2024, 10(2): 4-11 |
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Yadav U, Mehmood S, Ranjan R, Laul P. Serum lactate dehydrogenase levels in preeclampsia: Association with maternal and fetal outcomes. Caspian J Reprod Med 2024; 10 (2) :4-11
URL: http://caspjrm.ir/article-1-250-en.html
URL: http://caspjrm.ir/article-1-250-en.html
Department of Obstetrics & Gynaecology, Deen Dayal Upadhyay Hospital, New Delhi, India
Abstract: (3166 Views)
Background: Preeclampsia, a hypertensive disorder of pregnancy, is associated with adverse maternal and fetal outcomes. Serum lactate dehydrogenase (LDH) levels have been proposed as a marker of disease severity. This study investigates the association between LDH levels and maternal and fetal outcomes in preeclampsia.
Methods: This prospective study included 150 pregnant women beyond 28 weeks of gestation diagnosed with preeclampsia. Exclusion criteria included pre-existing conditions, multiple pregnancies, and substance use. Participants were stratified into mild (n = 100) and severe preeclampsia groups (n = 50) and further categorized by LDH levels: Group 1 (< 600 IU/L), Group 2 (600–800 IU/L), and Group 3 (> 800 IU/L). Clinical, laboratory, and fetal outcomes were assessed. Statistical analyses were performed using SPSS version 21.0, with a p-value <0.05 considered significant.
Results: Elevated LDH levels were significantly associated with severe preeclampsia (mean LDH: 966.0 ± 11.1 IU in severe vs. 567.6 ± 208.6 IU in mild cases; p< 0.001). Maternal complications, including disseminated intravascular coagulation (1.3%), eclampsia (2.7%), HELLP syndrome (2.0%), and acute renal failure (3.3%), were most frequent in group 3. Adverse fetal outcomes were more common in higher LDH groups, including low APGAR scores, low birth weight (≤ 2.5 kg in 28.7%), and increased neonatal intensive care unit (NICU) admissions (17.3% in Group 3).
Conclusion: Serum LDH levels correlate with preeclampsia severity and maternal-fetal complications. LDH> 800 IU serves as a valuable biomarker for predicting adverse outcomes, emphasizing its role in guiding clinical management. Further multicenter studies are warranted to validate these findings and improve care for preeclampsia patients.
Methods: This prospective study included 150 pregnant women beyond 28 weeks of gestation diagnosed with preeclampsia. Exclusion criteria included pre-existing conditions, multiple pregnancies, and substance use. Participants were stratified into mild (n = 100) and severe preeclampsia groups (n = 50) and further categorized by LDH levels: Group 1 (< 600 IU/L), Group 2 (600–800 IU/L), and Group 3 (> 800 IU/L). Clinical, laboratory, and fetal outcomes were assessed. Statistical analyses were performed using SPSS version 21.0, with a p-value <0.05 considered significant.
Results: Elevated LDH levels were significantly associated with severe preeclampsia (mean LDH: 966.0 ± 11.1 IU in severe vs. 567.6 ± 208.6 IU in mild cases; p< 0.001). Maternal complications, including disseminated intravascular coagulation (1.3%), eclampsia (2.7%), HELLP syndrome (2.0%), and acute renal failure (3.3%), were most frequent in group 3. Adverse fetal outcomes were more common in higher LDH groups, including low APGAR scores, low birth weight (≤ 2.5 kg in 28.7%), and increased neonatal intensive care unit (NICU) admissions (17.3% in Group 3).
Conclusion: Serum LDH levels correlate with preeclampsia severity and maternal-fetal complications. LDH> 800 IU serves as a valuable biomarker for predicting adverse outcomes, emphasizing its role in guiding clinical management. Further multicenter studies are warranted to validate these findings and improve care for preeclampsia patients.
Type of Study: Original Research |
Subject:
Obstetrics and Gynecology
Received: 2024/06/18 | Accepted: 2024/12/12 | Published: 2024/12/20
Received: 2024/06/18 | Accepted: 2024/12/12 | Published: 2024/12/20
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