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Enhanced outcomes following addition of gonadotropin-releasing hormone agonist during luteal support in frozen embryo transfers: a retrospective analysis
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Aamir Mahmood *    , Li Tan , Jie Zhang , Yan Li |
| Reproductive medicine Center, the Second Affiliated Hospital of Zhengzhou University, China , mahmoodaamir350@gmail.com |
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Abstract: (1482 Views) |
Background: Frozen embryo transfer (FET) has become a widely used technique in assisted reproductive technology (ART) cycles. Various protocols have been developed to optimize outcomes, including hormone replacement therapy followed by frozen embryo transfer (HRT FET) cycles and non-stimulated FET (NC-FET) protocols. Additionally, the use of gonadotropin-releasing hormone analogues (GnRH-a) in combination with FET has been explored. However, comparative studies evaluating the effectiveness of these protocols on clinical pregnancy and live birth rates are limited. This study aimed to assess the efficacy of addition of GnRH-a during luteal support in FET different on clinical pregnancy and live birth.
Methods: A retrospective cohort analysis was conducted on 3,515 data from patients undergoing FET cycles at the reproductive center of the Hospital of Zhengzhou University between February 2018 and December 2,021. Patients were divided into two groups based on the FET protocol utilized: GnRH-a (Triptorelin +existing treatment) group (1,033 patients) and non-GnRH-a group (existing treatment without Triptorelin) (2,458 patients) group. Clinical pregnancy rates and live birth rates were compared between these groups using appropriate statistical analyses.
Results: The study revealed significantly enhanced clinical pregnancy rates (58.0% vs. 48.4%; p=0.003) and live birth rates (52.7% vs. 45.6%; p=0.001) specifically for HRT-FET cycles compared to controls. However, no significant differences were observed between NC-FET groups. Similarly, no statistical difference emerged when comparing GnRH-a plus HRT-FET or stimulation-FET cycles to their respective controls regarding both clinical pregnancy rates and live birth rates. Notably, within the GnRH-a group, a 47% increase in clinical pregnancy rates and a 33% rise in live birth rates were noted.
Conclusion: Our findings suggest that HRT-FET cycles may be associated with improved clinical pregnancy and live birth rates compared to standard FET protocols. However, further studies are warranted to validate these results and explore the mechanisms underlying the observed differences in outcomes among different FET protocols. Additionally, the potential benefits of GnRH-a use in FET cycles warrant further investigation. |
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| Keywords: Enhanced outcomes, Frozen embryo transfer, Gonadotropin-releasing hormone agonist, Luteal support, Retrospective analysis |
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Full-Text [PDF 527 kb]
(371 Downloads)
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Type of Study: Original Research |
Subject:
Embryology
Received: 2023/09/11 | Accepted: 2023/12/1 | Published: 2023/12/20
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