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Male Infertility in infected patients with COVID-19: A Narrative Review
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Elias Kargar-Abargouei   , Esmaeel Ghani , Hamzeh Badeli-Sarkala , Mohammad Zamani Rarani , Zeinolabedin Sharifian Dastjerdi , Sakine Arab Firouzjaei , Maryam Arab Firouzjaei *  |
| Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran |
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Abstract: (4522 Views) |
Background: Since the emergence of the pandemic of coronavirus disease (COVID-19) through severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, we still have little knowledge about the mechanisms of pathogenesis of COVID-19. Surprisingly, early studies reported that men are more susceptible to COVID-19 compared to women. These findings raise the question of whether COVID-19 infection can negatively affect male fertility. Since angiotensin-converting enzyme-2 (ACE2) receptor, known as the entrance rout of virus into human cells abundantly on testicular cells, it is hypothesized that the virus can also have devastating effects male fertility.
Methods: The present study was conducted a narrative review of the literature on male infertility and COVID-19. We searched PubMed, Scopus, and Google scholar for papers. Full-text journal articles between the years 2019 and 2020 were reviewed for relevant articles.
Results: There is emerging finding, which provides support for the susceptibility of male reproduction health to COVID-19 infection. In the current review article, we documented an overview of male reproductive function manifestations and the possible male infertility mechanisms of COVID-19 infection. Certainly, clarifying the mechanism of these findings will lead to the timely management and treatment of infected patients.
Conclusion: This review suggests that male counseling about their fertility and the evaluation of their reproductive system function should be performed. |
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| Keywords: Angiotensin-converting enzyme-2 (ACE2), COVID-19, Male infertility, Oxidative stress |
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Full-Text [PDF 211 kb]
(1448 Downloads)
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Type of Study: Original Research |
Subject:
Reproductive Health
Received: 2021/05/16 | Accepted: 2021/06/25 | Published: 2021/06/27
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