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:: دوره 6، شماره 1 - ( 2-1399 ) ::
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Modification of non-invasive prenatal screening of Down syndrome: New approach using data mining analysis
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Background: The introduction of next generation sequencing (NGS) in recent decade to determine fetal aneuploidies through cell free fetal DNA (cffDNA) in maternal circulation has caused new challenges for conventional prenatal first and trimester screening. Limiting the conventional screening tests to the most powerful criteria would be an appropriate strategy in reducing the time around and cost of traditional tests before non-invasive NGS method.
Methods: In this study, the most important factors affecting the risk of Down syndrome was found using statistical and data mining analysis of pregnant women undergoing conventional prenatal screening.
Results: First trimester proteinuria, previous history of Down syndrome, consanguinity, nuchal translucency (NT) and inhibin-A were the most significant factors identified to be associated with the risk of Down syndrome.
Conclusion: Incorporating those critical factors into new screening software could be valuable in advance of cffDNA testing as a perfect accurate non-invasive prenatal screening.
     
نوع مطالعه: پژوهشي | موضوع مقاله: Reproductive Health
دریافت: 1399/1/1 | پذیرش: 1399/2/9 | انتشار: 1399/3/8
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Karami F, Sedaghat N, Kolivand S, Esmaeili M, Younesi S, Modarressi M H. Modification of non-invasive prenatal screening of Down syndrome: New approach using data mining analysis. Caspian J Reprod Med. 2020; 6 (1) :1-8
URL: http://caspjrm.ir/article-1-166-fa.html

Modification of non-invasive prenatal screening of Down syndrome: New approach using data mining analysis. نشریه طب تولید مثل خزر. 1399; 6 (1) :8-1

URL: http://caspjrm.ir/article-1-166-fa.html



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دوره 6، شماره 1 - ( 2-1399 ) برگشت به فهرست نسخه ها
Caspian Journal of Reproductive Medicine
Caspian J Repord Med: Infertility and Reproductive Health Research Center of Babol University of Medical Sciences, Babol-Amol old highway, after Mohammadhasan Khan bridge, Babol, Mazandaran, Iran, P.O. Box: 47135-547 Tel: +98-11-32274881-2 Fax: +98-11-32274880 E-mail: info@caspjrm.ir Website: www.caspjrm.ir
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