fa Maternal serum C - reactive protein and fibrinogen concentration in women with pre-eclampsia Obstetrics and Gynecology Obstetrics and Gynecology پژوهشي Original Research <p><b>Background:</b> Despite many studies published in recent years concerning pathogenic mechanisms of pre-eclampsia, but this issue remains controversial. The aim of the present study was to compare C-reactive protein (CRP) level and fibrinogen concentration obtained from pregnant women with pre-eclampsia with those obtained from women with normal pregnancies.&nbsp;</p> <div><b>Methods:</b> In a case-control study, 40 pregnant women with mild pre-eclampsia were studied. The maternal serum CRP and fibrinogen concentration of the 40 patients were compared with 55 pregnant women with non-preeclampsia as a control group. CRP was examined using quantitive nephlometry and fibrinogen concentration was measured by clotting system. An independent sample t-test was used for analysis.&nbsp;</div> <div><b>Results:</b> Maternal serum CRP was higher in women pregnant with pre-eclampsia compared with those from pregnant women normal pregnancies (p= 0.01). The independent t-test did not reveal any statistically significant differences in the fibrinogen concentration between these pregnant women, either with or without pre-eclampsia.&nbsp;</div> <div><b>Conclusion:</b> The findings of this study indicated that a novel increased CRP was identified among pregnant women with pre-eclampsia, making inflammatory marker as a promising new approach for the detection of pre-eclampsia.</div> CRP analysis, Female, Fibrinogen, Inflammatory marker, Pregnancy Complications 9 12 http://caspjrm.ir/browse.php?a_code=A-12-1-9&slc_lang=fa&sid=1 Mohammad Abedi Samakoosh 10031947532846001253 10031947532846001253 No Department of Nephrology, Mazandaran University of Medical Sciences, Sari Shahla Yazdani 10031947532846001254 10031947532846001254 Yes Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran Zinatosadat Bouzari 10031947532846001255 10031947532846001255 No Infertility and Reproductive Health Research Center, Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol Masoumeh Golsorkhtabaramiri 10031947532846001256 10031947532846001256 No Infertility and Reproductive Health Research Center, Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol