en Obstetrics and Gynecology Obstetrics and Gynecology پژوهشي Original Research <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:14.0pt"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Abnormal uterine bleeding (AUB) is a common gynecological challenge, stemming from various endometrial pathologies. This study aims to assess their prevalence, age distribution, symptomatology correlation, and compare sampling techniques.</span></span></span></span></span></span><br /> <span style="font-size:11pt"><span style="line-height:14.0pt"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> This prospective cross-sectional study was conducted at a single teaching institute, involving 150 female participants aged between 18 and 70 years who presented with AUB. Endometrial samples were collected using one of three methods: OPD Pipelle brush, surgical dilatation and curettage (D&C), or hysteroscopy.</span></span></span></span></span></span><br /> <span style="font-size:11pt"><span style="line-height:14.0pt"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The study found 41-50-year-olds most affected by AUB (40%), with 64% having given birth three or more times. Proliferative and secretory changes were common (35.3% and 16% respectively). Endometrial hyperplasia without atypia occurred in 12% and with atypia in 4.7%. Endometrial carcinoma was in 3.3% and polyps in 5.3% of cases. Heavy menstrual bleeding with normal duration affected 64%. Technical challenges included sampling failure in 2 pipelle biopsies and 7 D&C cases. Inadequate samples were obtained in 2 pipelle biopsy and 5 D&C cases. Uterine perforation occurred once, managed conservatively.</span></span></span></span></span></span><br /> <span style="font-size:11pt"><span style="line-height:14.0pt"><span style="text-autospace:none"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Our study underscores the burden of endometrial pathologies in AUB patients with predominant proliferative and secretory changes. Sampling challenges, particularly with pipelle biopsy and D&C, emphasize the need for refining methods and exploring alternatives like transvaginal sonography and hysteroscopy to enhance diagnostic accuracy and patient outcomes in AUB management.</span></span></span></span></span></span></div> Abnormal Uterine Bleeding (AUB), Cross-sectional Study, Endometrial Pathology, Endometrial Sampling Techniques, Evaluation 5 10 http://caspjrm.ir/browse.php?a_code=A-12-150-2&slc_lang=en&sid=1 Mahesh Asalkar mahesh@asalkarclinic.com 10031947532846002539 10031947532846002539 Yes Department of Obstetrics and Gynaecology, PGI-YCMH Pimpri Pune 411018(MS) India, Department of Obstetrics and Gynaecology,PGI-YCMH Pimpri Pune 411018(MS), India Ilaaf Rumani 10031947532846002540 10031947532846002540 No Mangal Supe 10031947532846002541 10031947532846002541 No Smita Thakkarwad 10031947532846002542 10031947532846002542 No Sinchana R 10031947532846002543 10031947532846002543 No