Caspian Journal of Reproductive Medicine
نشریه طب تولید مثل خزر
Caspian J Reprod Med
Medical Sciences
http://caspjrm.ir
1
admin
2423-5660
2423-5660
8
10.22088/caspjrm
14
8888
13
en
jalali
1399
2
1
gregorian
2020
5
1
6
1
online
1
fulltext
en
Modification of non-invasive prenatal screening of Down syndrome: New approach using data mining analysis
Reproductive Health
Reproductive Health
پژوهشي
Original Research
<strong>Background</strong>: The introduction of next generation sequencing (NGS) in recent decade to determine fetal aneuploidies through cell free fetal DNA (cffDNA) in maternal circulation has caused new challenges for conventional prenatal first and trimester screening. Limiting the conventional screening tests to the most powerful criteria would be an appropriate strategy in reducing the time around and cost of traditional tests before non-invasive NGS method.<br />
<strong>Methods</strong>: In this study, the most important factors affecting the risk of Down syndrome was found using statistical and data mining analysis of pregnant women undergoing conventional prenatal screening.<br />
<strong>Results</strong>: First trimester proteinuria, previous history of Down syndrome, consanguinity, nuchal translucency (NT) and inhibin-A were the most significant factors identified to be associated with the risk of Down syndrome.<br />
<strong>Conclusion</strong>: Incorporating those critical factors into new screening software could be valuable in advance of cffDNA testing as a perfect accurate non-invasive prenatal screening.
Data Mining, Down syndrome, Prenatal screening, Risk factor
1
8
http://caspjrm.ir/browse.php?a_code=A-12-120-2&slc_lang=en&sid=1
Fatemeh
Karami
10031947532846002015
10031947532846002015
No
Departement of Medical Genetics, Applied biophotonics research center, Science and Research Branch, Islamic Azad University, Tehran, Iran
Nafiseh
Sedaghat
10031947532846002016
10031947532846002016
No
Computing Science Department, Simon Fraser University, British Columbia, Canada
Sedigheh
Kolivand
10031947532846002017
10031947532846002017
No
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Maryam
Esmaeili
10031947532846002018
10031947532846002018
No
Department of Clinical Laboratory Sciences, Nilou Medical Laboratory, Tehran, Iran
Sarang
Younesi
10031947532846002019
10031947532846002019
No
Department of Clinical Laboratory Sciences, Nilou Medical Laboratory, Tehran, Iran
Mohammad Hossein
Modarressi
modaresi@tums.ac.ir
10031947532846002020
10031947532846002020
Yes
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran