en پژوهشي Original Research <strong>Background:</strong> Neglecting the sexual and reproductive health of the youth may potentially lead to high social and economic costs, both at present and in the future.&nbsp; The aim of this study was to assess the risk of sexual behavior and practice of Public college students in Harar, Ethiopia.<br /> <strong>Methods:</strong> A cross-sectional study was conducted across two public colleges in Harar, Ethiopia in 2019. 385 participants provided information on their socio-demographic characteristics, sexual behavior and practice, their risk perception towards HIV/AIDS, and STIs through a self-administered questionnaire. SPSS version 20 was used for data analysis.<br /> <strong>Results:</strong> The age range of the respondents was between 17 and 31. 207 out of 385 subjects were female. Around half 167 (43.4%) of the respondents were sexually active. About 33.5% of the respondents had experienced premarital sex before the age of 18. 52.2% of the participants had sexual activity with multiple partners. Among 31 (8.1%) of them developed a pregnancy; all pregnancies were unplanned and ended up with abortion, however.<br /> <strong>Conclusion:</strong> Significant numbers of students are assumed to have risky sexual behavior, which may increase an individual&#39;s risk of acquiring HIV/ AIDS. Accordingly, it is imperative that college students practice healthy behavioral modification through the use of such available services as condoms and contraceptives. Sexual activities, Sex behavior, Behaviors, Ethiopia, Public Health Student 1 5 http://caspjrm.ir/browse.php?a_code=A-12-102-5&slc_lang=en&sid=1 Arif Hussen arifhussen.ah@gmail.com 10031947532846001967 10031947532846001967 Yes Department of Pediatrics Nursing, Harar Health Science College, East Ethiopia, Ethiopia