RT - Journal Article T1 - Male Infertility in infected patients with COVID-19: A Narrative Review JF - Caspian-J-Repord-Med YR - 2021 JO - Caspian-J-Repord-Med VO - 7 IS - 1 UR - http://caspjrm.ir/article-1-171-en.html SP - 1 EP - 7 K1 - Angiotensin-converting enzyme-2 (ACE2) K1 - COVID-19 K1 - Male infertility K1 - Oxidative stress AB - Background: Since the emergence of the pandemic of coronavirus disease (COVID-19) through severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, we still have little knowledge about the mechanisms of pathogenesis of COVID-19. Surprisingly, early studies reported that men are more susceptible to COVID-19 compared to women. These findings raise the question of whether COVID-19 infection can negatively affect male fertility. Since angiotensin-converting enzyme-2 (ACE2) receptor, known as the entrance rout of virus into human cells abundantly on testicular cells, it is hypothesized that the virus can also have devastating effects male fertility. Methods: The present study was conducted a narrative review of the literature on male infertility and COVID-19. We searched PubMed, Scopus, and Google scholar for papers. Full-text journal articles between the years 2019 and 2020 were reviewed for relevant articles. Results: There is emerging finding, which provides support for the susceptibility of male reproduction health to COVID-19 infection. In the current review article, we documented an overview of male reproductive function manifestations and the possible male infertility mechanisms of COVID-19 infection. Certainly, clarifying the mechanism of these findings will lead to the timely management and treatment of infected patients. Conclusion: This review suggests that male counseling about their fertility and the evaluation of their reproductive system function should be performed. LA eng UL http://caspjrm.ir/article-1-171-en.html M3 10.22088/caspjrm.7.1.1 ER -