:: دوره 1، شماره 1 - ( 11-1393 ) ::
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Summer Savory (Satureja hortensis) Can Reduce Spermatotoxic Effects of Doxorubicin in Rats
:   (9178 مشاهده)

Introduction: Application of doxorubicin (DOX), an anticancer anthracycline antibiotic, carries the risk of serious dose-dependent toxicity to non-target tissues. The aim of this study was to investigate whether DOX-induced spermatotoxicity could be prevented by using the Satureja hortensis hydroalcoholic extract (SE).  

Methods: Male Wistar rats were randomly divided into four groups of six rats each. DOX was administered to two groups of rats in 5 equal intraperitoneal injections over a period of 4 weeks (accumulated dose of 20 mg/kg). One of these groups received SE at a dose of 100 mg/kg per day subcutaneously for 28 days along with DOX. A vehicle treated control group and a SE control group were also included.

Results: Epididymal sperm analyses revealed that DOX caused significant decreases in sperm concentration, viability and motility along with elevated sperm abnormality, while SE co-administration provided marked normalization in the sperm quantity and quality compared to the DOX-only treated group. 

Conclusion: It is reasonable to suppose that protective effects of SE against DOX-induced reproductive toxicity might have been related to the antioxidative and anti-inflammatory effects of this substance.

     
نوع مطالعه: پژوهشي | موضوع مقاله: Assisted reproductive technologies (ART)
دریافت: 1393/7/12 | پذیرش: 1393/9/24 | انتشار: 1393/10/1


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دوره 1، شماره 1 - ( 11-1393 ) برگشت به فهرست نسخه ها