:: Volume 1, Issue 1 (Caspian J Reprod Med 2015) ::
Caspian J Reprod Med 2015, 1(1): 1-6 Back to browse issues page
Summer savory (Satureja hortensis) can reduce spermatotoxic effects of Doxorubicin in rats
Ali Shalizar Jalali *, Gholamreza Najafi, Parisa Rahimzadeh
Urmia University, Urmia, Iran , ali_shalizar@yahoo.com
Abstract:   (9081 Views)

Introduction: Application of doxorubicin (DOX), an anticancer anthracycline antibiotic, carries the risk of serious dose-dependent toxicity to non-target tissues. The aim of this study was to investigate whether DOX-induced spermatotoxicity could be prevented by using the Satureja hortensis hydroalcoholic extract (SE).  

Methods: Male Wistar rats were randomly divided into four groups of six rats each. DOX was administered to two groups of rats in 5 equal intraperitoneal injections over a period of 4 weeks (accumulated dose of 20 mg/kg). One of these groups received SE at a dose of 100 mg/kg per day subcutaneously for 28 days along with DOX. A vehicle treated control group and a SE control group were also included.

Results: Epididymal sperm analyses revealed that DOX caused significant decreases in sperm concentration, viability and motility along with elevated sperm abnormality, while SE co-administration provided marked normalization in the sperm quantity and quality compared to the DOX-only treated group. 

Conclusion: It is reasonable to suppose that protective effects of SE against DOX-induced reproductive toxicity might have been related to the antioxidative and anti-inflammatory effects of this substance.

Keywords: Doxorubicin, Rat, Satureja hortensis, Sperm
Full-Text [PDF 170 kb]   (3480 Downloads)    
Type of Study: Original Research | Subject: Assisted reproductive technologies (ART)
Received: 2014/10/4 | Accepted: 2014/12/15 | Published: 2014/12/22

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