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:: دوره 2، شماره 2 - ( 9-1395 ) ::
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The suppressive effects of Simvastatin on fertility impairment induced by experimental unilateral testicular ischemia-reperfusion in mice
:   (3447 مشاهده)

Background: The basic pathophysiologic phenomenon in testicular torsion, a common urologic emergency, is ischemia followed by reperfusion. In this study, we evaluated the effect(s) of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory properties, on mouse epididymal sperm fertilizing potential and the subsequent in vitro embryo development in experimentally-induced unilateral testicular ischemia-reperfusion (IR).

Methods: Adult male mice were divided into four groups (n = 6, each). Following anaesthesia, IR was induced by clamping the left testicular vessels with an atraumatic microvascular clamp for 30 minutes in the IR group. In IR+SIM group, in addition, the mice received SIM (20 mg/kg per day) orally for 3 days starting from the day of induction of the experimental IR. A vehicle-treated control group and a SIM-only treated group were also included. Ipsilateral and contralateral epididymal sperms fertilizing capacity was analyzed in four groups after 35 days.

Results: Significant reduction in fertilization as well as blastulation rates were observed in the IR group. However, the SIM treatment considerably attenuated the IR-induced negative alterations in the above-mentioned parameters.

Conclusion: These findings revealed the repro-protective effects of SIM on the murine model of IR through the inhibition of oxidative injuries and inflammatory reactions.

     
نوع مطالعه: پژوهشي | موضوع مقاله: Embryology
دریافت: 1395/7/30 | پذیرش: 1395/9/17 | انتشار: 1395/9/22
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Shalizar Jalali A, Behfar M, Najafi G, Nourian A, Shahkarimi M, Koohestani M. The suppressive effects of Simvastatin on fertility impairment induced by experimental unilateral testicular ischemia-reperfusion in mice. Caspian J Reprod Med. 2016; 2 (2) :10-14
URL: http://caspjrm.ir/article-1-113-fa.html

The suppressive effects of Simvastatin on fertility impairment induced by experimental unilateral testicular ischemia-reperfusion in mice. نشریه طب تولید مثل خزر. 1395; 2 (2) :10-14

URL: http://caspjrm.ir/article-1-113-fa.html



دوره 2، شماره 2 - ( 9-1395 ) برگشت به فهرست نسخه ها
Caspian Journal of Reproductive Medicine
Caspian J Repord Med: Infertility and Reproductive Health Research Center of Babol University of Medical Sciences, Babol-Amol old highway, after Mohammadhasan Khan bridge, Babol, Mazandaran, Iran, P.O. Box: 47135-547 Tel: +98-11-32274881-2 Fax: +98-11-32274880 E-mail: info@caspjrm.ir Website: www.caspjrm.ir
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