[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 10, Issue 1 (4-2024) ::
Caspian J Reprod Med 2024, 10(1): 18-22 Back to browse issues page
Retrospective analysis of pregnancy outcomes complicated by systemic lupus erythematosus at a rural tertiary care center in Kerala, India
Jaimie T Jacob * , S Lakshmi Vinodh , Nisha V , Anamika Francis
Department of obstetrics & Gynecology, Government Medical College, Trivandrum, Kerala, India , jaimie.jacob@gmail.com
Abstract:   (868 Views)
Background: Systemic lupus erythematosus (SLE) affects women of childbearing age, leading to higher maternal and fetal morbidity and mortality. Disease flares during pregnancy complicate care. This study evaluates maternal and fetal outcomes in pregnancies complicated by SLE.
Methods: A retrospective analysis was conducted on 31 pregnancies complicated by SLE at the Department of Obstetrics and Gynaecology, TD Medical College, Alleppey, from January 2010 to December 2018. Data on maternal demographics, obstetric history, SLE manifestations, treatments, pregnancy outcomes, complications, disease flares, interventions, and delivery details were collected. Maternal complications, including gestational hypertension, pre-eclampsia/eclampsia, HELLP syndrome, diabetes, abruption, preterm birth, fetal growth restriction, lupus nephritis, and postpartum hemorrhage, were examined. Fetal outcomes were assessed based on perinatal morbidity and mortality and NICU admissions.
Results: Among the 31 pregnancies, 67% of the women were aged 20-30 years. SLE was diagnosed during the current pregnancy in 45.2% of cases, with 53.3% of these diagnoses occurring in the first trimester. Preterm birth was the most common complication, observed in 48.4% of pregnancies, with 29% live born and 19.4% stillborn. Hypertensive disorders were prevalent, with 38.7% developing pre-eclampsia/eclampsia. Antiphospholipid antibody positivity was noted in 29% of patients. Severe SLE flares occurred in 12.9% of patients, all with nephropathy in the third trimester.
Conclusion: Favorable pregnancy outcomes are more likely in women whose SLE activity is quiescent for at least six months before conception, without lupus nephritis, antiphospholipid syndrome, or superimposed preeclampsia. The findings emphasize the need for vigilant monitoring and management of pregnancies complicated by SLE.
 
Keywords: Female, Lupus Erythematosus, Systemic, Pregnancy, Pregnancy Complications, Pregnancy Outcome
Full-Text [PDF 309 kb]   (124 Downloads)    
Type of Study: Original Research | Subject: Reproductive Health
Received: 2024/06/1 | Accepted: 2024/06/28 | Published: 2024/06/30
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jacob J T, Vinodh S L, Nisha V, Francis A. Retrospective analysis of pregnancy outcomes complicated by systemic lupus erythematosus at a rural tertiary care center in Kerala, India. Caspian J Reprod Med 2024; 10 (1) :18-22
URL: http://caspjrm.ir/article-1-240-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (4-2024) Back to browse issues page
Caspian Journal of Reproductive Medicine
Caspian J Repord Med: Infertility and Reproductive Health Research Center of Babol University of Medical Sciences, Babol-Amol old highway, after Mohammadhasan Khan bridge, Babol, Mazandaran, Iran, P.O. Box: 47135-547 Tel: +98-11-32274881-2 Fax: +98-11-32274880 E-mail: info@caspjrm.ir Website: www.caspjrm.ir
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4660