TY - JOUR T1 - Modification of non-invasive prenatal screening of Down syndrome: New approach using data mining analysis TT - JF - Caspian-J-Repord-Med JO - Caspian-J-Repord-Med VL - 6 IS - 1 UR - http://caspjrm.ir/article-1-166-en.html Y1 - 2020 SP - 1 EP - 8 KW - Data Mining KW - Down syndrome KW - Prenatal screening KW - Risk factor N2 - Background: The introduction of next generation sequencing (NGS) in recent decade to determine fetal aneuploidies through cell free fetal DNA (cffDNA) in maternal circulation has caused new challenges for conventional prenatal first and trimester screening. Limiting the conventional screening tests to the most powerful criteria would be an appropriate strategy in reducing the time around and cost of traditional tests before non-invasive NGS method. Methods: In this study, the most important factors affecting the risk of Down syndrome was found using statistical and data mining analysis of pregnant women undergoing conventional prenatal screening. Results: First trimester proteinuria, previous history of Down syndrome, consanguinity, nuchal translucency (NT) and inhibin-A were the most significant factors identified to be associated with the risk of Down syndrome. Conclusion: Incorporating those critical factors into new screening software could be valuable in advance of cffDNA testing as a perfect accurate non-invasive prenatal screening. M3 10.22088/caspjrm.6.1.1 ER -