Caspian Journal of Reproductive Medicine

en Association between serum vitamin D levels and IVF–ICSI outcomes in women with polycystic ovary syndrome: A prospective cohort study Reproductive Health Reproductive Health پژوهشي Original Research <div style="text-align: justify;">Background: The association between vitamin D status and assisted reproductive technology outcomes remains uncertain, particularly in women with polycystic ovary syndrome (PCOS). This study evaluated the association between serum vitamin D levels and selected laboratory and pregnancy outcomes after vitro fertilization with intracytoplasmic sperm injection (IVF–ICSI) in women with PCOS. Methods: This prospective cohort study included 128 women with PCOS undergoing IVF–ICSI at Yas Hospital, Tehran, Iran (March 2017–March 2018). Serum vitamin D was measured on the day of oocyte retrieval. were categorized into two groups based on vitamin D levels: insufficient (<30 ng/mL; n = 83) and normal (≥30 ng/m; n = 45). Oocyte, embryo, and pregnancy outcomes were recorded. Analyses included independent-group comparisons and univariate logistic regression. Results: Mean age was 30.3 ± 3.9 years and mean body mass index (BMI) 24.6 ± 2.8 kg/m². Compared with the insufficient vitamin D group had higher mean numbers of mature (MII) oocytes (p = 0.016), embryos (p = 0.032), and grade A embryos (p = 0.001). Total oocyte count did not differ significantly. Forty participants (31.3%) had a positive chemical pregnancy test and 22 (17.2%) had a clinical pregnancy. Univariate logistic regression showed an association between vitamin D category and chemical pregnancy (p = 0.042). Conclusion: In women with PCOS undergoing IVF–ICSI, higher serum vitamin D levels were associated with better laboratory outcomes. However, the observational design and limited evidence regarding pregnancy outcomes preclude causal conclusions. Further prospective studies are needed to clarify the role of vitamin D in reproductive outcomes.</div> Fertilization in Vitro, Infertility, Female, Oocytes, Polycystic Ovary Syndrome, Pregnancy Rate, Vitamin D 11 16 http://caspjrm.ir/browse.php?a_code=A-12-176-2&slc_lang=en&sid=1 Naghmeh Pourmand No Firoozeh Akbari Asbagh No Mahbod Ebrahimi No Arash Jafarieh No Azadeh Falahatkar No Zahra Adib No Masoumeh Ghaznavi ghaznavimasumeh@gmail.com 0009-0005-0649-1685 Yes Department of Obstetrics and Gynecology, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran